Clinical Trial to Compare the Efficacy of 2% Monolaurin Shampoo and 2% Ketoconazole Shampoo

Edit..the cached version says: "Dela Cruz MDC., Verallo-Rowell VM. A double blind randomized controlled trial to compare the efficacy and safety of 2 % coconut b-monoglyceride Gel with 2 % monolaurin gel and 2 % ketoconazole lotion in the treatment of pityrosporum folliculits among adolescents and middle aged adults. 2005. On-going study for more subjects, 2007 "

But some interesting things about Monolaurin here: http://www.vmvrmd.com/dermatological-effects.php

For four years, monolaurin, in a continuing product stability study including post-market studies, has been found to successfully preserve a hypoallergenic cosmetic line of products, using no other preservatives, except this emollient ingredient (Verallo-Rowell and Moya, 2007).

All these papers confirm what initially was truly surprising: that on human skin, monolaurin is an antiseptic with broad-spectrum effects. A second surprise was its novel mechanism of action that sets it apart from other currently used antibiotics (Carpo et al, 2007).

Zinc oxide is a gold standard treatment for diaper dermatitis (DD) and irritant contact dermatitis (ICD). Last year, a resident’s award-winning RCT showed pure VCO better than zinc oxide in the treatment of DD (Martires, Montinola, Dizon,2006). Another study with similar results has just been finished using a more elegant preparation of VCO combined with zinc oxide for DD. This product also has potential use as a barrier to use in other irritant contact dermatitis, or for decubitus and other skin ulcers (Tiosudarmin and Verallo-Rowell, 2007).

Oral VCO in Dr. Dayrit’s study was shown to reduce HIV. Oral VCO also cleared the author’s case of Valacyclovir-resistant Herpes gingivo-stomatitis with erythema multiforme vasculitis (Carpo and Verallo-Rowell, 2007). To try to explain these effects of VCO, taken by mouth, in a small pharmacokinetic study, the monolaurin and lauric acid serum values were measured prior to intake of VCO and its control mineral oil. Measurements were repeated 1, 2, 4, and 6 hr after. Up to 6 hr with VCO, 1 hr with the control, a small amount of lauric acid and smaller amounts of monolaurin were detected in the blood (Malabanan-Guiyab and Verallo-Rowell, 2007).

A pilot study has also just been started to determine the nutraceutical and potential systemic antibiotic effect of oral monolaurin in atopic dermatitis (Toledo-Tan, Kusuma, Verallo-Rowell 2007).

I see nothing in this post indicating that 2% Monolaurin Shampoo also has the capacity to topically inhibit DHT.

Far as I can tell the comparative study all has to do with dermatitis and other skin disorders. Not with the topical inhibition of DHT which is why Ketoconazole shampoos are used as an adjunct treatment for hairloss.