United States Patent 5,470,861

United States Patent 5,470,861
Harmon Nov. 28, 1995

Method of promoting hair growth

Inventors: Harmon; Charles S. (Bloomfield, NJ).
Assignee: Hoffmann-La Roche Inc. (Nutley, NJ).
Appl. No.: 286,152
Filed: Aug. 4, 1994
Intl. Cl.: A61K 31/44
U.S. Cl.: 514/337
Field of Search: 514/337

References Cited

U.S. Patent Documents

4,971,982 Nov., 1990 Attwood et al. 514/337
5,028,711 Jul., 1991 Stenzel et al. 546/196

Foreign Patent Documents

9056007 Dec., 1990 AU  
9058725 Jan., 1991 AU  
9059751 Jan., 1991 AU  
9060134 Feb., 1991 AU  
9065644 May, 1991 AU  
0350805 Jul., 1989 EP  
0400430 May, 1990 EP  
0406656A1 Jun., 1990 EP  
0410208A1 Jul., 1990 EP  
0427606A1 Nov., 1990 EP  
3926001A1 May, 1989 DE  
2204868 May, 1988 GB  
WO86/00616 Jan., 1986 WO  
88/00822 Feb., 1988 WO  
WO92/14439 Mar., 1992 WO  

Other References

  • Uno, et al. Cyclic Dynamics of Hair Follicles and Effect of Minoxidil on the Bald Scalps of Stumptailed Macaques, The American Journal of Dermatology 7(3):283-297 (1985).

    Uno, et al. Stumptailed Macaques as a Model of Male Pattern Baldness Models Dermatol. vol. 3 pp. 159-169 (1987).

    Uno, H., The Stumptailed Macaque as a Model for Baldness: Effects of Minoxidil, International Journal of Cosmetic Science 8, 63-71 (1986).

    Abstract (Corresponding to WO 9214439) 1992.


Primary Examiner: Henley, III; Raymond
Assistant Examiner: Spivack; Phyllis G.
Attorney, Agent or Firm: Gould; George M., Johnston; George W., Coletti; Ellen Ciambrone

Abstract

The use of the compound 2-(6-cyano-3,4-dihydro-2,2-dimethyl-2H-1-benzopyran-4-yl)pyridine-1-oxide represented by the formula ##STR1## as well as pharmaceutically acceptable salts, as topical agents to promote hair growth is disclosed.

19 Claims, No Drawings

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